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The upper age of patients included was limited to 70 years to avoid the risk of less precise end point diagnosis in older patients.
Third, the upper age of study participants was 9 years and this meant that many highly cited studies describing associations between exposure and asthma risk in older children were not included.
However, CVD risk prediction models are not well validated in older people, for example the widely used Framingham risk equation is based on a patient cohort with an upper age of 74 [ 24].
The rate of progression of most lesions destined to become invasive cancer is generally considered to be slow, and one might therefore anticipate that a negative smear history before the age of 50 would considerably reduce the risk of positive cytology or histology in women aged 50 64 years (the upper age of invitation to screening in the UK), who have been regularly screened.
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The forward model, constrained by lower and upper ages of syn-orogenic deposits, traces the advance of the Outer Carpathian accretionary wedge and proves kinematic admissibility of the balanced and restored cross-sections.
Unlike this policy, in which the 6 month lower age of recommended vaccination has not changed as the upper age has increased, our experimental design maintained similar target group sizes by increasing both lower and upper ages of vaccination simultaneously.
It has extended the upper age for application of transplantation from 55 years for standard allogeneic transplantation to 70 years for RIC transplantation (Peggs et al, 2002).
All observations are censored 2 days after the new invitation was mailed (or on death, emigration, or after 2 years of observation for women passing the NBCSP upper age limit of 69 years of age).
Despite patients with rectal cancer across Europe having a median age at presentation of 71 years, an upper age limit of 70 years is mandated in BACCHUS because of these safety and futility concerns.
For instance, Ballenger et al. (1982) considered adolescence to extend to the age of 21, whereas most of the other studies used an upper age limit of 18.
35 36 Trials of HPV testing at the upper age limit of the screening programme ("exit test") and continued surveillance only of HPV positive women could provide important knowledge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com