In higher eukaryotes, the majority of bioactive peptides are synthesized as larger precursors, which, upon transit through the secretory pathway and in immature secretory granules, are processed by endo- and exoproteolytic cleavages.
We cannot, however, exclude that some TS cells directly switch from parental to inverted I-XCI upon HAT selection without transiting through a "two-active-X" state.
These studies suggest that METH induces autophagy as a pro-survival response in endothelial cells, which transits into apoptosis upon continuous exposure to the drug.
Nanog /– MEFs transduced with retroviral transgenes encoding Oct4, Klf4, Myc and Sox2 transited to pluripotency upon transfection with mNanog or zNanog, but not an empty vector transgene (supplementary material Fig. S3A,B).
Using chromatin immunoprecipitation, followed by ChIP-seq, a high-throughput sequencing technique, chromatin changes upon transition from HF-SCs to transit-amplifying progenies (HF-TA) have been characterized.
It is also central to cell signalling, as upon dissociation from E-cadherin, it transits to the nucleus to alter transcriptional profiles (Mason et al, 2002; van de Wetering et al, 2002).
Upon the addition of DNA, the σ RNAP quickly transits through the RPc and readily forms the RPo complex, and only the closed clamp conformation was observed.
