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Upon topical application of sulfoxymethyl and chloromethyl derivatives of HMF, the mice were found to develop papillomas on their skin.
Despite the fact that mast cells have CGRP receptors [9, 10], no activation or sensitization of meningeal nociceptors could be detected upon topical or systemic administration of this compound in rats [8].
In this study a polyglycerol-based tNG with diameter of 156 nm was investigated for penetration and release properties upon topical application on ex vivo human skin with intact or disrupted barrier.
His lighter fare did not hesitate to touch upon topical issues, drawing analogies between a football game and patriotism, or chewing gum and diplomacy and economic relations with Mexico.
Mechanistically, it is generally thought that upon topical application, DNCB or other chemicals with a similar structure, such as 2,4-dinitrofluorobenzene and picryl chloride, can complex with various skin proteins to form covalent conjugates and thereby function as immunogen(s).
Upon topical TPA treatment, ERK activity was gradually stimulated, reaching a plateau approximately 6 hr later.
Similar(45)
Some drawbacks of reconstructed skin models relate to their highly permeable skin barrier compared to normal skin and the morphological changes and decrease in epidermal layers typically seen during prolonged culture and upon repeated topical application of vehicles.
Upon arrival, a topical anesthetic (EMLA cream; Aztrozeneca, Wilmington, DE) was applied to the antecubital area of both arms and an hour later a flexible intravenous catheter was inserted into both of the arms.
At present there is no clear evidence, however, of the impact of topical corticosteroids upon cough.
Changes in the structural properties of ethyl cellulose/propylene glycol dicaprylate systems (EC/PGD), intended for topical drug delivery, upon addition of water were investigated.
In this study, a novel sustained release proniosomal system was designed using sugar esters (SEs) as non-ionic surfactants in which proniosomes were converted to niosomes upon skin water hydration following topical application under occlusive conditions.
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