Another important problem with most of the existing anti-mycobacterials, is their inability to act upon latent forms of the bacillus.
Existing first and second generation antipsychotic drugs based upon the dopamine hypothesis are limited by their inability to treat all symptom domains and their undesirable side effect profiles.
However hMSCSYT-SSX1 did not undergo transformation, as assessed by their inability to form tumors upon subcutaneous and sub-capsular renal injection into immunocompromised mice.
Of note, V o2max increased significantly only in responders, suggesting that the nonresponders' inability to raise V o2max despite improved maximum power output reflects their inability to increase fATP upon exercise training.
PHD3 methylation in carcinoma cells was associated with their inability to appropriately upregulate PHD3 mRNA upon exposure to hypoxia.
In these experiments, SIRT1-/ mousembryonicic fibroblasts (MEFs) fail to upregulate p19ARF upon serial passaging in normal culture conditions, correlating with their inability to undergo replicative senescence.
Community medical services fail to meet the needs of older people with dementia, because of their focus upon acute 'treatable' conditions, their lack of outreach, and their inability to provide education and long-term support to family carers [ 52].
By this time the steady drain of men and money was telling so severely upon the confederacy that some of the most loyal allies protested their inability to render further help.
Despite expression of the memory marker CD45RO, resting neonatal NKT cells were also reported to be functionally immature as defined by their inability to produce IL-4 or IFN-γ upon primary activation and only acquired their effector functions after cell division, implying that in vivo activation and peripheral expansion are necessary to attain functional maturation [32], [51].
People with T2DM both construct and draw upon causal accounts as a resource, and a means to counter their inability to balance medical outcomes and quality of life.
