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As the first step to design even more effective drugs based upon the structure of fisetin, the present study investigated the structural requirements for the anti-amyloidogenic activity of fisetin by comparing the effects of several structurally related flavonoids on Aβ fibril formation in vitro.
Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized.
A novel series of cyanoguanidine-piperazine P2X7 antagonists was designed based upon the structure of A-740003.
The question of its relationships hinges upon the structure of the ankle joint, a pivotal character in understanding the evolution of archosaurs.
"Based upon the structure of this group, their associations and connected events, there is a reasonable suspicion that these persons pose a threat to national security," the document said.
Her new "Arena," which is based upon the structure of ballroom dances, will be presented by Susan Marshall and Company Thursday through Saturday nights at the Bessie Schonberg Theater.
Similar(31)
This range was selected based upon knowing the structure of the associations in the example.
L. Bragg, then still a student in Cambridge, in which, by analysis of the Laue diagrams _of zinc blende, he determined the correct lattice upon which the structure of this crystal is built.
Upon phosphorylation, the structure of the SH3 domain becomes more rigid, in particular at the level of the RT and distal loops that are locked in a defined conformation.
Upon solving the structure of Pdr16p, Yuan et al. [19] entertained the hypothesis that the much larger lipid pocket of Pdr16p compared to Sec14p or Sfh1p may accommodate some new substrates in addition to PI or PC.
Both the efficiency and enantioselectivity of the biocatalysis, however, were strongly dependent upon the structures of both nitrile and amide substrates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com