Sentence examples for upon targeting from inspiring English sources
Interestingly, clear differences were observed upon targeting distinct epitopes of the same receptor.
Upon targeting using transferrin ligands, the nanoparticles showed enhanced cellular uptake and synergistic cytotoxicity in ~ 92% of cells, particularly in iron-deficient microenvironment.
Upon targeting, Cas9 generates DNA double-strand breaks (DSBs) and facilitates the repair or insertion of mutations, insertion of recombinase recognition sites, or large DNA elements.
Here, we report that TLQP-21 is intrinsically disordered and undergoes a disorder-to-order transition, adopting an α-helical conformation upon targeting cells expressing the C3aR1.
There are at least two obvious features that must be considered upon targeting specific metabolic pathways/enzymes for drug development: the pathway must be essential and the enzyme must allow the design of pharmacologically useful inhibitors.
Distinctive features of the in vitro FUEL signal include a macroscopic depth dependency, a lack of enhancement upon targeting at a constant fluorophore concentration cf and a non-square dependency on cf. Significantly, FUEL is an important, so far overlooked, component of all resonance phenomena which should guide the design of appropriate controls when elucidating interactions.
Coffinier, C. et al. Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF-1β.
Fluorescence from internalized RNA persists for ≥2 h, suggesting a sizable window for aptamer payloads to exert influence upon targeted cells.
An empirical method is described for developing and optimizing immunoassays on the CombiMatrix ElectraSense® microarray based upon targeted deposition of polypyrrole (Ppy) and capture Ab.
10.7554/eLife.08474.006 Figure 2. Decreased ULBP1 expression upon targeted mutation of screen hits.
Identical phenotypes, namely an arrest of mammary gland development before outgrowth of the primary sprout, occur upon targeted deletion of PTHrP or the receptor PTHR1 [ 14].
