Sentence examples for upon ptp from inspiring English sources

The fact that monomeric EGFR was inefficiently ubiquitinated upon PTP inhibition, but displayed a similar phosphorylation on Y1045 as compared to EGF stimulation, suggests that rather than Y1045 phosphorylation alone, the formation of EGFR oligomers is a decisive factor for c-Cbl binding and efficient ubiquitination.

(C ) Anisotropy of spontaneously activated EGFR-QG-mCitrine upon PV-mediated PTP inhibition.

Upon Cys mutation, PTP opening is reduced to a level similar to that in CypD-negative cells (Linard et al. 2009; Nguyen et al. 2011).

Whether cytochrome c can be released upon depolarization-induced PTP opening or due to accumulation of dysfunctional mitochondria remains to be determined.

We and others have established that PTPs have essential roles in zebrafish embryonic development by analysis of phenotypical defects upon knockdown of target PTP expression, including RPTPα [18], [19], PTPψ [20], Shp2 [21] and PEZ [22].

Here, we present data demonstrating the efficient silencing of the wt Ad5 pTP gene upon transduction with amiRNA expression vectors.

At these low concentrations, inhibition of adenoviral replication mediated by HSV-TK expression alone became marginal; however, it was restored to normal levels upon concomitant knockdown of pTP gene expression by pTP-mi5.

The baculovirus protein tyrosine phosphatase-encoding gene ptp, however, induces ELA upon infection [ 5, 11].

Upon measuring the dose-dependent inhibition of total PTP activity from lysates of E. coli that overexpress either wild-type Shp2 or C333P Shp2, we find that the activity of wild-type Shp2 lysate is inhibited in a dose-dependent manner, with an apparent IC50 of 6 μM, whereas the activity of C333P Shp2-expressing lysate is unaffected at concentrations up to 25 μM.

In agreement with the results on the isolated PTP domain, we found that Shp2-FL undergoes strong inhibition upon being incubated with FlAsH.

{text{RPP}} = {text{MAP}} - {text{IAP}}where MAP = mean arterial pressure {text{FG}} = {text{GFP}}{text{PTP}} = left( {{text{MAP}}{text{IAP}}} right){text{IAP}} = {text{MAP}}2 times {text{IAP}}where GFP = glomerular filtration pressure, PTP = proximal tubular pressureThus, changes in IAP have a greater impact upon renal function and urine production than will have changes in MAP.