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This bias towards reduced gene expression upon mobilization may suggest that downregulation of genes actively maintaining HSC quiescence is an important mechanism of cytokine-induced HSC expansion.
While self-renewal capacity is attenuated as HSC differentiate into MPP, self-renewing divisions increase upon mobilization and in leukemic HSC.
Alternatively they were isolated form peripheral blood (PB) of healthy donors upon mobilization with granulocyte-colony stimulating factor (G-CSF) before leukapheresis procedure for allogeneic stem cell transplantation.
Pain assessments are usually performed at rest; pain upon mobilization or coughing is not verified.
Do surface immune molecules change their expression on HSCs upon mobilization, infection, and in extramedullary organs?
Upon mobilization of TAG by TAG lipases, activated fatty acids could serve as substrates either for β-oxidation or as building blocks for membrane formation.
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On the other hand, the Serbs could muster some 450,000 men to oppose the Austro-Hungarians upon full mobilization.
We report that the underlying DNA sequence can control the initial direction of translocation, translocation distance, as well as the new positions adopted by nucleosomes upon enzymatic mobilization.
Enrichment of these genes may reflect a differential requirement for certain metabolic effectors in the transition from a largely quiescent and metabolically inactive HSC to a highly proliferative and metabolically active cell upon differentiation, mobilization or transformation.
Upon store mobilization, STIM redistributes into 'puncta' adjacent to the plasma membrane, where it activates Ca2+-permeable SOCs (store-operated channels) [ 16].
They are maintained within bone marrow (BM) stem cell niches and released upon induced mobilization (see below), as firstly demonstrated by Asahara and colleagues [ 12].
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