Although the controversies of the Reformation dealt more with the definition of faith than with either hope or charity, the Reformers identified the uniqueness of God's agāpe for man as unmerited love; therefore, they required that charity, as man's love for man, be based not upon the desirability of its object but upon the transformation of its subject through the power of divine agāpe.
Conversely, after Hdac6 is restored to the nucleus upon cellular transformation, it may re-direct Tip60-p400 to a subset of its target genes that are normally stem cell-specific, potentially eliciting changes in gene expression that promote cancer development.
This was not a result of cell-cycle changes upon transformation, because transformed G1/S arrested cells had higher levels of phosphorylated H1 than G1/S arrested untransformed cells [ 25].
Connexin expression is usually down-regulated upon malignant transformation, but it can also mediate tumour cell endothelial interactions during tumour diapedesis [ 20].
The silencing of Id4 in cancers raises an important question: what is the normal physiological function of Id4 in at least those tissues which upon transformation leads to its loss of expression such as the prostate?
Constitutive production of superoxide was induced upon Ras transformation in NIH3T3 cells, and depletion of its dismutated metabolite H2O2 suppressed the uncontrolled growth of Ras-transformed cells.
However, in the luminal breast cancer lines MCF7 and T47D, these genes were induced by GATA3 overexpression, suggesting that upon transformation, GATA3 may change its function to support cancer progression.
The lethality phenotype was specifically due to the RNAi/DUT1 construct as it was not observed upon transformation with an empty vector (RNAi/0).
Described as "insensitive" and "harsh", her honesty touched upon the transformation of western societies by the "invisible" power of PR and lobbying.
Professor Thompson's current research focuses upon the transformation of technical work during the transition from silent to sound motion pictures in the American film industry.
