Sentence examples for upon its activation from inspiring English sources

Notably, MS4a4B expression enhanced the production of the calcium/calmodulin-dependent protein kinase (CaM kinase) IIα, also known as Camk2a, whose kinase activity is dependent upon its activation by calmodulin (CaM).

We first tested whether growth factor could activate ETK kinase activity using phosphorylation of tyrosine 40 (Y40), an autophosphorylation site by ETK upon its activation [8], as readout.

Upon its activation by D-Alanine 2, Leucine 5 Enkephaline (DADLE, selective DOR agonist) in hUCB-BFs under oxidative stress, a significant down regulation (~ 2 folds) of key UPR genes was observed as determined by qPCR, Thioflavin-T protein aggregation assay and western blot analysis.

An emission to an edge, going out from a vertex upon its activation, takes place only when the realisation of a corresponding process in a given simulation experiment is a certain random event (resulting from the probability of this event occurrence or from the conditions of a decisive emitter).

However, we could detect the decrease in full length CD46 upon its activation (not shown).

Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such as rosiglitazone, PPAR-γ regulates adipogenesis, glucose uptake and inflammatory responses.

Upon its prolonged activation, NFκB induces the expression of the noncanonical IκB kinases IKKε and TBK1.

However, so far very few studies have dealt with whether and how NFATc1 signaling is attenuated upon its initial activation.

In contrast, β2AR recruits another PDE variant upon its agonist activation, PDE4D5, via its interaction with βarrs following its GRK-dependent phosphorylation [ 6, 7, 12- 16].

In the present study, we identified ROS-activated JNK as a crucial p53 co-regulator, revealing a strategy to switch the p53 transcriptional response from growth arrest to apoptosis upon its pharmacological activation.

We have previously used the caspase BiFC approach to interrogate the caspase-2 pathway and reported that it was a robust and specific method to measure induced proximity of caspase-2 upon recruitment to its activation platform, which is the most apical step in the activation of caspase-2.