Sentence examples for upon inhibiting from inspiring English sources

Furthermore, both drugs still inhibited HIF-1α protein expression upon inhibiting its degradation with desferrioxamine.

Most endocrine therapies for breast cancer treatment and prevention depend upon inhibiting the proliferative effect of oestradiol on oestrogen receptor (ER -positive tumour or normal mammary ER -positiveells.

We find DNA damage and stress response activation upon inhibiting Hdacs1,2, which corroborates previous findings that loss of Hdacs1,2 causes severe mitotic catastrophe [ 8].

As also RISC loading was enhanced upon inhibiting MVB turnover by Hps4 knockdown (Lee et al, 2009), the authors argued that MVBs might also be sites of RISC disassembly, and possibly RISC loading.

Much greater reduction in the toxicity was observed upon inhibiting the NADH dehydrogenase and MAPK (which were identified by the dual-response analysis), than for the stearoyl-CoA desaturase (SCD) activation (which was identified for the TG-alone analysis).

This assay relies upon inhibiting the process of bone resorption in rapidly growing animals at the periosteal surface (the "funnel region") of the metaphysis, and the aspect of metaphyseal trabeculae in the marrow cavity that is opposite to the nearby epiphyseal growth cartilage.

Moreover, oral delivery of large amount of immunogens easily elicits oral tolerance and is challenged by stomach acids upon ingestion, inhibiting the usage of oral vaccines (Holmgren et al., 2003; Levine, 2003).

The endogenous lipids arachidonic acid and anandamide exert opposing effects upon GlyT1a, inhibiting (IC50 ∼ 2 μM) and potentiating (EC50 ∼ 13 μM) transport currents, respectively 185.

Electrochemical impedance spectroscopy (EIS) results implied that the increase of capacity retention and rate performance could be mainly attributed to the coating layer, which suppressed the increase in impedance upon cycling by inhibiting the electrolyte/electrode parasitic reaction.

The anti-inflammatory agent sodium aurothiomalate appears to act upon mononuclear phagocytes, inhibiting their lysosomal enzyme activity.

B56 γ is also known to mediate dephosphorylation and stabilization of the tumor suppressor protein p53 upon DNA damage, inhibiting cellular proliferation and transformation.