Sentence examples for upon impairment from inspiring English sources

Alternatively, there may exist additional roles of myosin Va within the muscle fibre which led to an increased fatigue resistance upon impairment of the motor protein.

To further characterize the HIPK2 subcellular distribution observed upon impairment of Y354 phosphorylation, colocalization analyses were performed with organelle-specific Abs.

Such a phenotype can be observed upon impairment of the RNA surveillance machinery or in cells from ICF (Immunodeficiency, Centromeric region instability, Facial anomalies) patients, in which TERRA is upregulated because of DNA methylation defects in the subtelomeric region.

Besides its engagement in the Mdm2/Mdm4 KO/KI studies, p53 was found to be activated upon impairment of ribosome biogenesis in several RP-deficient mouse models (Bursac et al., 2014).

We hypothesized that the loss of SDCCAG8 and NPHP4 immunolabeling of Rpgrip1 nmf247 photoreceptors reflect a loss of antigenicity upon impairment of their RPGRIP1-dependent chaperoning, sorting or targeting that may mask or promote the proteolysis of epitopes.

Both transcripts are reported to be severely decreased upon liver-specific STAT5 deletion as well as upon systemic impairment of GHR signaling.

In the present case more emphasis is laid upon the impairment of the obligation of the contract of the lessees to surrender possession and of the new lease which was to have gone into effect upon October 1, last year.

CONCLUSIONS: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.

could be attributed to hypothalamic dysfunction and that this brain region undergo important gene expression changes upon Mecp2 impairment [22], we assessed the expression of our observed Mecp2-null mice upregulated genes in the hypothalamus.

The temporal correlation depicts the accumulation of detergent (NP40 -SUb proteiNP40 -SUbing early uproteinseasoccurringrmearly

Furthermore, we examined levels of p62/SQSTM1, a known autophagy substrate accumulating upon autophagy impairment [ 20].