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In two cases the donor acceptor distances were similar in the unfolded and the folded state and, as a consequence, the kinetic changes in energy transfer upon folding were very small.
Our NMR studies showed that residues with high average area buried upon folding (AABUF) parameter collapsed to form the clusters.
Companies, because of financial pressure or to recoup expenses upon folding, might sell off their patents or license the assertion rights to a PAE for a percentage of any money extracted.
Local hydrophobic collapse of the polypeptide chain and transient long-range interactions in unfolded states of apomyoglobin appear to occur in regions of the amino acid sequence which, upon folding, bury an above-average area of hydrophobic surface.
Thus, there is a larger entropic gain to peptide folding in the presence of larger cosolutes due to the greater reduction in volume excluded from cosolutes upon folding.
Despite this variability, these proteins adopt upon folding comparable three-dimensional structures, that are characterised by an internal hydrophobic core supporting three protruding fingers [4].
Similar(33)
However, it is worth to consider that upon protein folding both motifs could be brought close enough to allow them to work cooperatively as a stronger motif.
Limiting scenarios may be encountered in cases of high molecular weight aggregates or upon compaction, folding, and binding.
Upon protein folding this motif is masked and the resulting complexes can undergo ER export (Ma et al. 2002).
Spacers of various lengths separate these regions, but their acidic residues are brought together upon protein folding to form a catalytic triad essential for transposition [ 8- 11].
Disordered proteins are usually involved in folding upon binding [ 28].
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