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Two biological examinations were performed: upon entering the study and 1 week later.
All enrolled subjects received comprehensive clinical and neurological examinations, and provided detailed medical, headache, and drug histories upon entering the study.
Subjects during the ictal stage received 24-hour ambulatory ECG monitoring using a Holter monitor (MyECG E3-80 porecorderecorder, Microstar Inc., Taipei, Taiwan) upon entering the study.
Upon entering the study, patients were randomized into two study groups using the Random Allocation Software (version 1.0): the HA group was treated with physical therapy + subacromial injection of HA (40 mg sodium hyaluronate/2 mL, OSTENIL® TENDON, MW 1.6 MDa), and the control group was treated with physical therapy only.
We found that IFNβ recipients who became PRs already had higher levels of disease activity and disease burden, as measured by MRI, upon entering the study.
Upon entering the study, subjects visited the lab for a briefing to practice the experimental task and to collect an Actiwatch (Actiwatch, Philips Respironics, USA) that they were instructed to wear at all times until the conclusion of the experiment.
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Furthermore, upon entering the present study, the diagnosis of the 81 patients with NPSLE and its classification was reconfirmed by hospital case records.
Furthermore, upon entering the present study, the diagnosis of the 72 patients with NPSLE and its classification was reconfirmed by referral to rheumatologists in charge as well as by review of hospital case records in each institution.
A final limitation is that patients were identified by their initial allocation to biweekly or monthly treatment in the RCTs but were allowed to change dosing frequency at two time points upon entering the OLE study.
Upon entering the major in Religious Studies, a student is assigned a faculty advisor whose area of expertise most closely matches the proposed interest of the student.
Written and informed consent will be obtained from parents or guardian and all participants over 12 years of age, by study coordinators and personnel, upon entering the trial before matching and randomisation.
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