K. Crofton described a pathway based upon disruption of thyroid hormone metabolism during development, including agents, targets, and outcomes linked by this mode of action.
Intriguingly, wbk contains several genes that, upon disruption, do not generate R phenotypes.
Many D. radiodurans genes previously implicated in resistance, but for which no sensitive phenotype was observed upon disruption, are absent in D. geothermalis.
This enzyme is exclusively intracellular and is released into the culture supernatant upon disruption of the plasma membrane integrity, as a result of apoptosis or necrosis.
These compounds are hydrolyzed by an endogenous thioglucosidase, myrosinase, releasing toxic products upon disruption of plant cells by harvesting, processing, or mastication [28].
However, SAHF formation in MEFs is less pronounced than in human fibroblasts [27] and senescent MEFs can rapidly re-enter cell cycle upon disruption of the p53 pathway [47].
Finally, we show that a relevant cargo (pro-apoptotic cyt c) can be delivered into macrophages, and upon disruption of endosomes, the cargo is released and can perform its biological function (activation of the caspase cascade).
To date, three DNA polymerases, Polβ [25], [26], Polγ [27] and Polζ [28] are known to lead to embryonic death in mice (after E18.5, E7.5 and E9.5, respectively) upon disruption.
These observations suggest that prolonged silencing of neuronal activity leads to increased mobility of α7-nAChRs, thereby favoring their internalization by endocytosis, as seen upon disruption of actin microfilaments.
Since there was no candidate for the transcriptional regulator whose expression level was up- or down-regulated upon disruption of mutS, mutL, or mutS2 gene (data not shown), it can be speculated that a constitutively expressed transcriptional regulator is responsible for the regulation of the vitamin B1-dependent ROS-detoxifying system upon inactivation of DNA repair enzymes.
PABP1 was redistributed upon disruption of polysomes with EDTA treatment.
