For Richter transformation, we recommend allo-HCT upon demonstration of an objective response to anthracycline-based chemotherapy.
For example, how do you incentivize large companies to develop drugs that need to be used sparingly — through tax credits, efficacy payments upon demonstration of effective treatments or extending patent exclusivity?
Upon demonstration of the benefits of sorafenib, the patients ineligible for sorafenib therapy due to medical reasons wee also included.
Upon demonstration of a persistent viable tumor or intrahepatic distal recurrence at imaging follow-up, TACE was repeated "on demand".
Assessment of true gametocytocidal efficacy of any drug will depend upon demonstration of the ability to block transmission to mosquitoes.
Thus, diagnosis of leakage typically rested upon demonstration of hemoconcentration, yet hemoconcentration below the WHO threshold of 20% has been noted previously in DSS patients [ 11].
In the last years, microRNAs have attracted scientific interest upon demonstration of their alteration in response to various diseases: they have been proved to affect the crucial steps of carcinogenesis acting as oncogenes or oncosuppressors [ 4].
Upon demonstration by biochemical and biological activity assays that the LBD of LasR receptor proteins can fold into a functional conformation in the absence of its cognate acyl-HSL ligand, SERS spectroscopy allowed us to obtain direct experimental evidence of conformational changes in LasRLBD upon interaction with activators and inhibitors of P. aeruginosa quorum sensing.
Upon demonstration that HMBQ-Nap 1 allows for class-selective detection of GSH, Cys, and Hcy under low probe/analyte conditions, an investigation was undertaken to examine the ability of HMBQ-Nap 1 to act as a an imaging agent for the presence of these biological thiols in human cells.
Transcatheter arterial chemoembolisation was repeated 'on demand' upon demonstration of a persistent viable tumour (i.e., the absence of complete response (CR)) or intra-hepatic distal recurrence at imaging follow-up, provided that liver function had not deteriorated (Child-Pugh score >7).
There was no other way to prevent the "almost murderous feeling" that could lead to "demonstrations upon the floor, which in the present state of excitement, would almost certainly lead to a general melee and perhaps a dozen deaths in the twinkling of an eye".
