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It is very likely that the 39 kDa subunit is also involved in conformational changes upon deactivation.
For the first time, we demonstrate that ND3 is not the only subunit to become exposed upon deactivation of mitochondrial complex I.
The fact that the A/D transition has a high activation energy [ 10] favours the idea of significant conformational changes upon deactivation.
Sfp1p is activated by the TOR1 and PKA pathways and is regulated by shuttling between the nucleus in its active form and the cytoplasm upon deactivation.
Complete localization of T-3-BP-AuNPs at 12 h might also be due to the opening of the VDACs upon deactivation of HK2 by 3-BP.
Exposure of Cys-39 of the ND3 subunit upon deactivation is one of the main conformational changes identified in complex I to date.
Similar(45)
Activation upon depolarization and deactivation upon repolarization of the mutants appeared similar to those of the wild type.
The optimum location depends upon the deactivation level of the catalyst and the relative dependence of catalyst properties (rate constants, effective diffusivities) upon position during deactivation.
Permanent LVAD support can induce new and irreversible pathological changes in normal heart valves which become the lethal pathophysiology upon device deactivation [ 28, 29].
Upon the deactivation of the ABC transporters by NaN3, there is no ABC efflux pumps-associated alkane efflux during alkane import.
It presented features of slow anion channels [41], slow activation upon hyperpolarization and slow deactivation upon depolarization [45], although part of the instantaneous current could have been carried out by fast activating anion channels as described for guard cells [46].
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