Used and loved by millions
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com
upon binding of the
Grammar usage guide and real-world examplesUSAGE SUMMARY
The phrase "upon binding of the" is correct and usable in written English.
It can be used in contexts related to programming, contracts, or agreements where an action occurs as a result of a binding event. Example: "Upon binding of the contract, both parties are obligated to fulfill their respective duties."
✓ Grammatically correct
Science
Alternative expressions(18)
upon morphology of the
upon incubation of the
upon discovery of the
upon modification of the
upon news of the
upon examination of the
upon review of the
upon nonpayment of the
upon learning of the
upon unification of the
upon approval of the
upon startup of the
upon release of the
upon activation of the
upon hearing of the
upon comparison of the
upon assessment of the
having been advised of
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Human-verified examples from authoritative sources
Exact Expressions
59 human-written examples
The resulting fluorescent signal occurs upon binding of the oxidized dye to nucleic acids.
Science
Upon binding of the fourth inhibitor the dimer interface, however, becomes partially disordered.
Science
In addition, βA αA loop residues at the N-terminal underwent smaller chemical shift perturbation upon binding of the phosphopeptide.
Science
Upon binding of the RCA template, Phi29 DNA polymerase and dNTPs were used to initiate the RCA reaction.
Science
Upon binding of the l-Phe inside the pockets, PDT transits from an open to a closed conformation.
In addition, residues 16 22 of the MshA structure without substrate are disordered but become well-ordered upon binding of the UDP substrate.
Science
Upon binding of the target proteins onto the encoded microbeads, monoclonal anti-HSA and monoclonal anti-hCRP detection antibodies labeled with blue UCNPs were added.
Science
Interestingly, these are the exact regions that previously showed decreased deuterium exchange upon binding of the RIα regulatory subunit of PKA.
Science
Upon binding of the fusion protein to the cell of interest, the diphtheria toxin is internalized which results in protein synthesis inhibition and subsequent cell death.
Furthermore, the enzyme undergoes induced fit upon binding of the inhibitor bestatin, leading to a movement of the C-terminal domain.
Science
On the contrary, upon binding of the specific target protein onto the primer through the protein-small molecule interaction, the HCR will be inhibited due to the steric and allosteric effect.
Expert writing Tips
Best practice
When using "upon binding of the", ensure that the subsequent clause clearly states the consequence or result of the binding event. This enhances clarity and avoids ambiguity.
Common error
Avoid using "upon binding of the" without explicitly stating what happens as a result. For example, instead of "Upon binding of the protein", use "Upon binding of the protein, the enzyme becomes activated."
Source & Trust
84%
Authority and reliability
4.5/5
Expert rating
Real-world application tested
Linguistic Context
The phrase "upon binding of the" functions as a prepositional phrase that introduces a condition or trigger for a subsequent event. As Ludwig AI confirms, it is frequently employed in scientific and technical contexts to denote a cause-and-effect relationship.
Frequent in
Science
100%
Less common in
News & Media
0%
Formal & Business
0%
Wiki
0%
Ludwig's WRAP-UP
In summary, the phrase "upon binding of the" is a grammatically correct prepositional phrase predominantly used in formal, scientific contexts to establish a temporal and causal relationship. As Ludwig AI indicates, its high frequency in scientific literature underscores its role in detailing cause-and-effect relationships in biological and chemical processes. To ensure clarity, subsequent clauses should clearly articulate the consequences of the binding event. While common in scientific writing, it's less appropriate for informal or general contexts. Always specify what happens as a direct consequence of the binding to enhance understanding.
More alternative expressions(10)
Phrases that express similar concepts, ordered by semantic similarity:
following the attachment of the
Replaces "upon binding" with "following the attachment", focusing on the temporal sequence after the binding event.
subsequent to the ligation of the
Emphasizes the chronological order and uses the term "ligation" which is similar to "binding" in a scientific context.
after the interaction with the
Substitutes "binding" with "interaction", broadening the scope to include any form of interaction, not just binding.
once the combination with the
Replaces "upon binding" with "once the combination", highlighting the completion of the binding process as a trigger for subsequent events.
in response to the association of the
Focuses on the cause-and-effect relationship, indicating that something happens as a direct reaction to the binding.
as a result of the adherence of the
Highlights the outcome of the binding process, emphasizing the consequence of the adherence.
triggered by the union of the
Emphasizes that the binding event acts as a trigger for a subsequent action or reaction.
consequent to the complex formation with the
Uses more formal language to describe the binding event, referring to it as a "complex formation".
given the linkage with the
Highlights the establishment of a link or connection as the condition for a subsequent event.
dependent on the connection of the
Emphasizes the dependency of a process or event on the formation of a binding or connection.
FAQs
How can I use "upon binding of the" in a sentence?
The phrase "upon binding of the" is typically used in scientific or technical writing to describe a process that is initiated or altered when one molecule or substance attaches to another. For example, "Upon binding of the ligand to the receptor, a signaling cascade is initiated."
What are some alternatives to "upon binding of the"?
You can use alternatives such as "following the attachment of the", "subsequent to the ligation of the", or "after the interaction with the" depending on the context.
Is "upon binding of the" formal or informal?
"Upon binding of the" is generally considered formal and is best suited for scientific, technical, or academic writing. It might sound out of place in casual conversation.
What grammatical structure usually follows "upon binding of the"?
Typically, "upon binding of the" is followed by a noun phrase specifying what is binding, and then a clause describing the resulting action or state. For example, "Upon binding of the antibody to the antigen, the complex precipitates."
Editing plus AI, all in one place.
Stop switching between tools. Your AI writing partner for everything—polishing proposals, crafting emails, finding the right tone.
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Source & Trust
84%
Authority and reliability
4.5/5
Expert rating
Real-world application tested