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They were often showered by good fortune, but relied at crucial moments upon achievements of individual will.
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Onyx obtained Kyprolis through one of its own acquisition, that of privately held Proteolix, in 2009 for $276 million upfront, with up to $575 million more dependent upon achievement of various milestones.
Upon achievement of certain operating and financial goals within the next two years, the purchase price can mount up to a maximum of $9 million in cash.
FDG infusion and PET imaging were initiated upon achievement of steady state glucose infusion, at 98±3 min after the initiation of insulin infusion.
P4P is defined as payment issued upon achievement of a predetermined performance target [ 3].
Subsequently, creation of ALI-culture conditions depended upon achievement of confluence for P0 cultures and upon achievement of a TEER threshold value of 50-100 Ω·cm2 for P1 cultures, an indicator for the presence of functional tight junctions [ 37].
CQUIN funding is up to 1.5% of contract outturn value, conditional upon achievement of quality outcomes specified in the contract.
Consolidation therapy, aimed at preserving remission, is paramount to treatment of AML upon achievement of a CR.
Whereas the first pathway is induced early upon achievement of asexual developmental competence (day 1), induction of the latter pathway is delayed (day 3).
According to this model, data collection and data analysis activities constitute a continuous, interactive process that is complete upon achievement of data saturation.
Upon achievement of haemodynamic stability during deep anaesthesia, protective ventilation was started with the reduction of minute volume, titrated to reach an arterial partial pressure of carbon dioxide (PaCO2) greater than 70 mmHg.
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