Upon ligand binding, Notch1 undergoes a concerted action of the proteolytic enzymes ADAM (a disintegrin and metalloprotease)/TACE [TNF (tumor necrosis factor -converting enzyme]/γ-secretase that ultimately release the NICD (Notch1 intracellular domain).
Professors look favorably upon students who are putting a concerted effort into learning the material and doing their best to improve their knowledge and skills, as opposed to merely focusing on the grade.
PETF and PCY show a concerted down-regulation upon iron limitation as expected for constitutive photosynthesis genes, and in agreement with the observed down-regulation of photosynthesis in response to iron limitation.
Since the original Th1/Th2 dichotomy emerged, it has become clear that in most instances resistance to infection requires a concerted Th2 response, dependent upon the nexus of IL-4Rα-mediated signalling [ 2,11].
Despite a concerted effort to improve upon existing self-report questionnaires to optimize children's recall ability [ 11], the findings presented here may be indicative of difficulties collecting self-report data from young children.
Similarly, at local levels there needs to be a concerted move away from focusing upon the day-to-day administration of existing NHS dental contracts towards the more robust commissioning of NHS dental services by NHS England's Local Area Teams.
Upon starvation, the respective Atg proteins are recruited in a concerted manner to the single site of autophagosome formation, the so-called phagophore assembly site (PAS), which is located in close proximity to the yeast vacuole.
The crystal structure of MtSK (this work) and that of Erwinia chrysanthemi SK suggest a concerted conformational change of the LID and SB domains upon nucleotide binding.
A concerted up-regulation of SAA1, S100A12 and F3 was found upon stimulation by LPS.
Interestingly, in fission yeast, polarized bouquet configuration is maintained until the end of meiotic prophase, and upon entry into the first meiotic division, telomeres dissociate from the SPB in a concerted manner, dubbed 'telomere fireworks' [ 5].
