Sentence examples for uphill change from inspiring English sources

The results reported here are consistent with the requirement that TIM undergo an energetically uphill change in conformation from an inactive open conformation to an active closed form, which is driven by the intrinsic phosphodianion binding energy.

However, Campbell claims it was an uphill battle to change a company culture of misogyny and that leadership blocked her efforts to make changes that would be more friendly to women.

Does the ground beneath their feet change — uphill, downhill, side hill?

But critics like Mr. Lockyer and Mr. Blumenthal face an uphill battle to change the Wall Street system.

Birth control advocates also hope that the legal ruling and the EEOC decision could help them in their uphill struggle to change the laws regarding contraception in America.

Pat Fenlon's side have put together a decent run heading into Sunday's game, but they face an uphill task to change the record books, which are stacked heavily in the Champions' favour.

And so you're operating against that demonstration of rescue and so you've got a kind of uphill battle to change that presumption.

If libraries are mainly staying clear of the uphill battle to change copyright law, Google isn't.

It is an uphill battle to change a hierarchical culture into one that fosters this dichotomy of democracy and dictatorship.

Sometimes these experts will inspire action, but most of the time, financial advice is like diet advice: no matter how much it is backed by scientific evidence or how easy it might be to implement, it's an uphill battle to change your eating habits, just as it has been for a gazillion people who have tried before you.

But he suggested that PG&E had an uphill task given climate change.