Sentence examples for upfront use from inspiring English sources

In Her2-positive advanced breast cancer, the upfront use of trastuzumab is well established.

While addressing one aspect of the sequencing debate, such upfront use clearly then raises a whole raft of new questions about management on development of CRPC.

Plerixafor can be applied with three strategies: (i) identification of patients with risk factors for poor mobilization and upfront use of plerixafor.

In addition, trials examining newer agents in the castration-naïve setting are now beginning to emerge, potentially supporting the upfront use of agents such as docetaxel.

In particular, clinical trials have shown that NSCLC patients whose tumors harbor sensitizing EGFR mutations significantly benefit from the upfront use of an EGFR TKI, rather than conventional chemotherapy.

Both combined and sequential single agents are acceptable options; however, if not contraindicated by the conditions of the patient and if feasible with an acceptable toxicity profile, there is no reason to delay the upfront use of active agents.

Also, Time Warner Cable works on a calendar year, Ms. Gillman says, rather than the fall-to-spring season that the upfronts use.

Seddiq said alleged first-time offenders, including one minor, were being held unless they could pay an entire $10,000 bond in cash – practically unheard of in a city where defendants pay deposits upfront and use loans from bondsmen.

The press and Wall Street tend to focus on the upfront and use it as a barometer for the health of television media, but it's a faulty barometer.

Price has been upfront about using a ghost-writer, but her own voice comes through loud and clear, particularly when berating her heroine's family for not being supportive of a wayward 17-year-old who wants to get plastic inserted into her knockers to make a career out of other people's masturbation.

Merkle was required to pay for the surgery upfront and used a credit card.