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The CROP study design took a pragmatic approach to study the optimal treatment for an RRPC cohort by comparing (deferred) ADT and upfront cryotherapy by using metastasis-free survival as a primary end point.
Patients were treated upfront according to study-specific guidelines (Supplementary Table 1).
What makes the present study different from the previous series is the ratio of upfront to salvage intervention.
Here we studied Pt- GpG) DNA adducts in circulating tumour cells (CTC) treated with cisPt- GpGin meDNAm upfront to systemic theradductsm patinnts with advancirculatingll-cell lung cancer (NSCLC).
With this pilot study, we show the feasibility of measuring platinum adduct persistence ex vivo in extracted CTC upfront to systemic therapy.
Time can be saved by applying synthesis methods upfront to direct design and downstream analysis efforts.
Surveys cannot be presumed upfront to be of minimal risk.
However, with the technique used in our study, we are able to test adduct persistence in extracted epithelial CTC and in white blood cells during a 24-h period upfront to systemic administration.
ERCC1 mRNA levels were measured in selected CTC isolated upfront to cytotoxic chemotherapy.
Patients should be educated upfront to optimize success and compliance with the management strategy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com