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If this were done, the model again predicts that an AI upfront strategy is optimal.
They also favour an upfront strategy to sequencing after 2 years of tamoxifen, but in this case the differences are small and model-dependent.
If this is a true estimate of the difference in this subgroup and the hazard ratio for an AI starting after 2 years of tamoxifen is 0.65 and after 5 years is 0.60, then a switching strategy after 2 years dominates an AI upfront strategy for this subgroup, both in terms of recurrence rates at 10 years (15.2 vs 13.2%) and time lost to recurrence (0.6 months difference; Table 2).
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Find serious artists with connections, and offer them an unusually high (say 100%) percentage of the royalties, plus some upfront cash Strategy #4: Blog about your dilemma for Free Exchange, and hope some comic fans – or even industry insiders - are reading.
According to a statement from the theater on Tuesday, the 2012 summer festival drew financial support from more than 1,000 donors who contributed a total of $1 million before the productions were staged – an upfront financing strategy intended to assure that the Intiman shows did not end in debt if ticket sales were low.
Current ASCO [131] and European Guidelines [132] recommend the incorporation of AIs in the endocrine treatment plan as switch (2 3 years) or upfront therapy strategy (5 years).
A recent Japanese multi-institutional prospective study including 1194 patients (76% with lung cancer) suggested that the upfront SRS strategy is reasonable for patients with up to 10 lesions [ 15].
So if you're among those fortunate enough to choose which investors get into your initial seed round, be sure to ask the right questions that will allow you to glean their follow-on strategy upfront.
This observation has generated debate regarding the optimal treatment strategy (upfront AIs vs switch) for postmenopausal ER/PgR-positive breast cancer.
Any asset manager, or any company bidding to run the whole system, will be required to disclose any conflicts of interest upfront and propose strategies for minimizing them.
The difference in averaged hazard ratios between the upfront and switching strategies is not statistically significant when a heterogeneity test is employed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com