Upfront staging RPLND in all patients was favored only by a small minority of panelists (supplementary material S9, available at Annals of Oncology online) [ 9, 25– 29].
Patients with normal serum tumor markers and equivocal retroperitoneal metastases in CT or MRI scans should be followed closely by repeat scanning or in case of a non-seminoma may receive upfront staging retroperitoneal lymph-node dissection (RPLND) or before a definitive treatment decision is made.
If the hidebound network schedule was to change, it would logically follow that the annual springtime rite of selling commercial time after glitzy, elaborately staged upfront presentations would change, too.
Upfront don't do stage shows in plush West End theatres, or the sort of safe and cosy comedy clubs that are still overwhelmingly white.
Mr. Zucker said the strike might make it possible to change, among other things, the method for developing series, which tends to be concentrated in an intense period every winter and spring, and the garish upfront presentations the networks stage every May to sell their new shows to advertisers.
All four patients with a relapse located at the primary site had been treated upfront without local radiotherapy (3 stage I, 1 stage II) (Supplementary Table 2).
So persuasive was Mr. Koolhaas, supported by Mr. Broad, that only after announcing their plans did the trustees seemed to grasp that this tabula rasa approach would force the entire complex to shut down for three years and require all the money to be raised upfront, rather than in stages.
According to a statement from the theater on Tuesday, the 2012 summer festival drew financial support from more than 1,000 donors who contributed a total of $1 million before the productions were staged – an upfront financing strategy intended to assure that the Intiman shows did not end in debt if ticket sales were low.
Combined use of immunotherapy and targeted therapy upfront in very early stages of cancer utilizing sophisticated CTC detection as a guideline as to the therapy time window may prove to be effective in preventing metastasis and improve cancer mortality.
For the first time NBC decided to stage an Olympic upfront — a special sales presentation for advertisers in advance of an event (as is done before every prime-time television season).
