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In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy.
Moreover, the role of whole brain radiation in the upfront setting remains to be determined.
TMZ has been examined in the upfront setting in the elderly patient population.
In the upfront setting, patients with up to ten BM principally received SRS.
In addition, a variety of new drugs registered in relapsed disease are being studied in the upfront setting [ 16].
Additionally, because of the use of TMZ with radiotherapy in the upfront setting in GBM, these results are somewhat anachronistic.
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CEO of Professional Science Editing for Scientists @ prosciediting.com