For example, the subset of TNBC tumors with low RB/E2F target genes and intact RB most probably has a very poor response to chemotherapy, and would have more benefit from other treatment options upfront, as opposed to progressing through relatively ineffective chemotherapy.
Appearing before a crowd of around 250 at the annual Sustainable Operations Summit at the Hilton New York in Midtown Manhattan, the former president said there had been some progress but that the upfront costs of adopting better technology — especially in shaky economic times — and a cultural resistance to change remained significant obstacles.
One alternative approach has been the selecting out those patients who would progress early with an upfront CRT approach.
Others, shy at first, open up and improve as the session progresses; Alsop's guidance is upfront and encouraging, without dodging the difficult issues.
Thus, for patients with resectable or borderline resectable disease by CT scan and high (>180 U ml−1) CA19.9, we usually administer chemotherapy upfront and explore surgically those patients who do not progress after two cycles of treatment provided laparoscopic assessment of peritoneal disease is negative as well.
This deal includes upfront payments, equity investments, payouts at each important stage of progress and a supply contract.
Progression-free survival (PFS) was not used as an endpoint in this study, as 36% of patients have been shown to progress during the surgery-related break when treated with upfront sunitinib before planned nephrectomy (as in the SUMR protocol) and, therefore, PFS does not act as a good surrogate marker (Powles et al, 2011).
"Don't pay more than one-third of the total amount upfront," he said, adding that the balance should be paid only as work progresses.
In order to further activate the therapeutic progress against acute myeloid leukemia (AML), we recently proposed cross-trial networking based on general upfront randomization and a common standard arm.
