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In this group of upfront patients resected, the sensitivity of MR, CT and CEUS did not differ statistically.
Such analysis might allow us to identify upfront patients in the future who will not tolerate aromatase inhibitors and should have another endocrine treatment.
A remarkable finding was the fact that a positive SRS was more frequently noticed in relapsing MM patients than in upfront patients.
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Upfront patient selection and treatment stratification seem to be of utmost importance.
Besides clinical grouping according to the above-mentioned criteria, age and frailty are used for upfront patient stratification, although particularly frailty is not well defined.
In the lesion-by-lesion analysis 175 resected lesions were evaluated: 67 38.3%) belonged to upfront resected patients (group-A) and 108 (61.7%) to chemotherapy-pretreated patients (group-B).
In the upfront setting, patients with up to ten BM principally received SRS.
Therefore, it is important to identify upfront those patients who will be affected by the omission of radiotherapy.
Another strategy would be to test the afatinib and cetuximab combination upfront in patients with EGFR mutation-positive advanced NSCLC.
Upfront, all patients were scheduled to be postoperatively monitored either at an intensive care unit (ICU) or at a prolonged stay at the post-anesthesia care unit (PACU).
4 This prospective multicenter study examined the relevance of using the SLN procedure upfront for patients with extensive microcalcifications on mammography and treated by mastectomy.
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