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Mr. Acebes insisted that any accusation that the government was covering up evidence was untrue, saying, "We will carry on about being cautious and upfront about our investigation".
The goal of this trial was to determine if there was enough biologic activity of TMZ with BV in the upfront setting to merit further investigation in larger scale randomized controlled trials, specifically for the unresectable population.
The upfront approach to treatment of glioblastoma in the unresectable population warrants further investigation in randomized controlled phase III trials.
We had anticipated before this investigation that the survival results would be worse in patients undergoing salvage treatment than in those receiving upfront treatment, but there was, in fact, no significant difference between these two groups (Table 3).
Whether a combined MET EGFR inhibitory strategy as upfront treatment is superior to MET inhibition used only after EGFR-TKI monotherapy failure should be the subject of further investigation.
"Rich was very upfront.
It's all upfront.
"He was upfront.
Be upfront and direct d.
Let's be upfront.
Announce potluck upfront!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com