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One anonymous blogger has been providing daily updates of the trial in English, with information provided by an unknown "tipster" and selected translations from Chinese-language newspapers provided by a "C.F.," or Chinese friend.
In addition, a one-page Mel-D trial synopsis detailing the inclusion and exclusion criteria has been placed in the surgical consulting rooms and frequent updates of the trial progress are reported at the MIA research meetings.
In contrast to this, the most frequently selected option amongst patients for when to share results with participants was to provide regular updates of the trial's progress, (46; 58.2%).
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It was also unnerving to hear updates on the trial of Dzhokhar Tsarnaev, the Chechnya-born Muslim man who, with his late brother Tamerlan, is charged with bombing the Boston marathon, and now might face the death penalty.
I read this heart-breaking story right after listening to the latest update on the trial of the alleged killer of Angie Zapata, a young Colorado woman brutally murdered in 2008 because she was transgendered.
By publishing updates of the ongoing trials, we hope to bring basic and translational scientists who work on breast cancer closer to the clinic by exposing them to the unanswered clinical questions.
In the latest update of this trial, with a median follow-up of 100 months, anastrozole significantly increased DFS in the hormone receptor-positive population by 74.2% versus 70.1% for tamoxifen (HR 0.85, 95% CI 0.76 to 0.94, P = 0.003) [ 13].
The 2005 Journal of the National Cancer Institute update of the British Columbia trial (Table 3) confirmed these earlier data [ 12]; a recent analysis from the Danish trials also showed that the survival benefits were similar in both nodal groups [ 13].
The latest update of the ATAC trial revealed reduced libido in significantly more patients receiving anastrozole (1%) than tamoxifen (<1%; P = 0.0001) [ 42].
In the most recent update of the IES trial [ 19], deaths from cardiac events were similar in exemestane and tamoxifen groups (22.1% versus 20.9%, P = 0.34).
However, a recent update of the MOSAIC trial suggests that with further follow-up, the benefit of OX is not of the magnitude that was expected, particularly in elderly patients (Mayer, 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com