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We have clarified the naming convention in several places in the main text and updated the strain table (Supplementary file 1).
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In order to improve the structural modelling with an affordable computational effort, the contributions by present model are incorporated updating the strain energy of a C0 parent eight-node plate element based on the First Order Shear Peformation Plate theory and through a post-processing procedure based on spline interpolation of the involved quantities.
As in this article's companion, we updated the average cell strain by defining a correction factor ("strain factor"), based upon the elastic response.
As the biomass composition has obvious effects on the model validation and the strain improvement, we updated the cell composition of P. pastoris.
We have updated the Methods section of our manuscript to make clearer our strain construction procedures (please see the subsection headed "Yeast strains and culture conditions").
Global fracture simulations are preformed to update the target fracture strain and to compute the corresponding failure onset displacement.
In sharp contrast, group I-v 2006∼2008 had ω>10 and LRT>60, which provided strong evidence for positive selection (Table 1, 2) and agreed with the necessity to update the A(H1N1) vaccine strain using A/Brisbane/59/07 for the 2008∼2009 season.
Therefore, an iterative scheme needs to be implemented where the soil properties are updated based on the strain level until the maximum strain for all layers converge.
The annually updated vaccine strains are generated in the laboratory by reassortment with viruses more closely related to the currently circulating ones.
Starting from an initial value, these parameters are updated till the computed strain field matches the experimental strain field.
Many of the strains used are from the Burkholderia cepacia complex experimental strain panel and updated experimental strain panel [ 29, 87].
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