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We first confirmed the observation of modular essentiality in S. cerevisiae using an up to date manually curated set of "gold-standard" protein complexes (Pu et al. 2009) and the method of Hart et al. (fig. 1, see Materials and Methods).
The ideal is to have a configuration management database, but to keep that up to date manually is generally impossible.
BJ: I used to work in growth equity and my cofounder worked in banking, and we were both having to keep a lot of data up to date manually, which was a problem we wanted to automate.
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She brought it up to date.
It also keeps everyone up to date.
Keep it up to date.
Keep things up to date.
Ensure your game is up to date.
Keep your skill set up to date.
Thus, to fulfill the existing gap in the available biodegradation databases, we report here an up-to-date and manually curated database with an associated query system that exploits a phylogenomic analysis of aerobic degradation of aromatic compounds AromaDeg.
However, when we used a more up to date and manually curated list of subunits of macromolecular complexes (Pu et al., 2009), we found that statistically significant attenuation in proteins that form part of complexes takes places in all the strains.
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