Altogether, our findings unveil a novel link between PHGDH and differentiation that may have important clinical implications.
Our findings unveil a pathway linking the Rac activator DOCK7 to a microtubule regulatory protein and highlight the contribution of microtubule network regulation to axon development.
Our findings unveil a novel mechanism of action for the drug metformin with implications for the molecular basis of epigenetic dysregulation in cancer.
Our findings unveil a role for IL-15 as a critical mediator in defense against systemic candidiasis and hold promise for the design of IL-15-based antifungal immunotherapies.
These findings unveil a previously unrecognized developmental potential of hPSC and present the first embryoid model for studying post-implantation human amniotic sac development, which is drastically different from that in mice26, 27.
Altogether, these findings unveil a previously unexplored role of PHGDH in the regulation of self-renewal and stemness factors (KLF4, Oct4, Nanog, Sox-2, and Lin28B) in cancer stem-like cells.
Together, our findings unveil a conserved molecular toolbox fundamental to metazoan biology that contains a number of neuronally expressed and disease-related genes, and reveal a key role for TBCEL/coel-1 in regulating microtubule function during metazoan development and neuronal differentiation.
Numerical results unveil a number of insightful findings, e.g., that sizable cost savings are observed for the intersecting bimodal design as compared to the single-mode designs for moderate to high demand levels, and that only moderate benefits are observed as compared to the trunk-feeder designs under certain operating conditions.
Our experimental results unveil a number of important findings.
Thus, these findings unveil a novel mechanism regulating OIS.
Our findings unveil a novel interplay between AMPK and HSF1.
