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We provide evidence that in breast cancer cells BRCA1 is involved in XIST regulation on the active X chromosome, but not in its localization as previously suggested, and that XIST can be unusually expressed by an active X and can decorate it.
In addition to pollen having its own complement of unusually expressed genes, other clusters (Regulons 3, 29, 43, and 52) are highly upregulated in pollen but also in other tissues.
In a previous study of HSPGs, we showed that stromal syndecan 1 was an adverse prognostic factor for ovarian cancer and that syndecan 3 was unusually expressed by the vasculature (Davies et al, 2004).
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Large positive PEM scores for a gene in a particular tissue indicate that the gene is unusually highly expressed in that tissue, relative to its expression in other tissues [ 31].
Interestingly, analyzing the unusually highly expressed miRNA miR-122, they showed that coexpression of miR-122 target genes was achieved specifically at extremely high target site abundance.
The GOseq package version 1.18.0 [ 44] was used to identify GO categories with unusually many or unusually few differentially expressed genes in the merged dataset.
Pancreatic tumour cell lines are known to produce a plethora of proteases (Kitamura et al, 2000) and unusually to express receptors for angiogenic growth factors of the VEGF family (Itakura et al, 2000).
Categories with unusually many differentially expressed genes represented functions, processes, or cellular components that were affected by the transgene, while categories with unusually few differentially expressed genes represented processes that were resistant to perturbation by the transgene.
CAIRO, Oct. 16 — Egypt expressed unusually strong support on Tuesday for the Bush administration's efforts to hold an international conference this fall to begin negotiating peace between the Israelis and the Palestinians.
The researchers found that placentas from sick women expressed unusually high levels of RNA coding for a protein called endoglin, which also plays a role in the vascular system.
Dressed in shimmering long robes designed by Oana Bothe-Ban, the dancers — Mr. Solomons, Hope Clarke and Carmen de Lavallade — participated in a triangular contest of lovers that was expressed in unusually formal terms for Mr. Solomons.
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