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Whether the unusual anticodon GCU of tRNASer in Mytiloida mitogenomes is related to the unusual inheritance of mtDNA?
We discuss how these allelic variants could influence Cox-2 gene expression, and account for the unusual inheritance of RD in dogs.
Both loci showed unusual inheritance patterns for the disease allele when comparing outcomes in heterozygous affected children with outcomes in affected children of heterozygous mothers.
Both loci show unusual inheritance patterns for the disease allele when comparing outcomes in heterozygous affected children with outcomes in affected children of heterozygous mothers, and modeling suggests either an effect of mother's genotype or parent-of-origin effects.
We suggest that the unusual inheritance pattern of RD is due to these alleles, either by changing the pattern of expression of Cox-2 or making Cox-2 levels susceptible to influences of other genes or environmental factors that play an unknown but important role in the development of RD in dogs.
Although such mechanisms of meiotic drive or segregation distortion have not been previously described in T. gondii, they might explain the unusual inheritance pattern of ChrIa.
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An even more interesting feature of bivalves is the presence of an unusual mitochondrial inheritance system: the doubly uniparental inheritance (DUI; Skibinski et al. 1994; Zouros et al. 1994).
In 1994, Reed B. Wickner provided genetic evidence that a long known genetic element of the budding yeast Saccharomyces cerevisiae with unusual cytoplasmic inheritance was in fact a prion [5].
Ghiselli F, Milani L, Guerra D, Chang PL, Breton S, Nuzhdin SV, et al.: Structure, transcription, and variability of metazoan mitochondrial genome: perspectives from an unusual mitochondrial inheritance system.
Seven bivalve lineages (Mytilidae, Unionidae, Margaritiferidae, Hyriidae, Donacidae, Solenidae, and Veneridae) have been found to have an unusual mode of inheritance for mtDNA, termed doubly uniparental inheritance (DUI) [ 7].
Incomplete erasure at genes associated with a measurable phenotype results in unusual patterns of inheritance from one generation to the next, termed transgenerational epigenetic inheritance.
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