PCNA can also undergo SUMOylation during replication in the absence of DNA damage (Hoege et al, 2002), a modification that contributes to the recruitment of the Srs2 helicase to the replication fork to prevent untimely recombination during S phase (Papouli et al, 2005; Pfander et al, 2005).
I was what I think you'd call, in layman's terms, a total frickin' mess; angst-ridden, physically ill from all the stress and convinced I was going to die because, for some reason, I'm certain that every new life phase includes my untimely demise.
Management issues identified as barriers to revised treatment implementation were inadequate socialization, no clear policy on phase-in of AL and phase-out of SP, untimely supply of RDTs and AL, lack of information about the RDT's effectiveness, and a lack of monitoring.
To conclude, we have proposed that photoperiodic mechanisms, interacting with inadequate or untimely illumination and a genetic tendency for phase delay, produce depression.
In order to avoid an untimely transition to the extremely cold-sensitive generative phase [ 19] before or during winter, and to facilitate the accumulation of sufficient resources for reproduction, winter-annual and biennial plants growing in temperate zones require vernalization for induction of flowering.
Thirdly, low supplies of deoxyribonucleoside triphosphates (dNTPs) during S phase, a condition that may arise from untimely S phase entry and altered replication dynamics, can severely retard RF progression (Alvino et al. 2007; Beck et al. 2010; Bester et al. 2011).
The performance of the existing RAIM method, however, may not meet more stringent aviation requirements for availability and integrity during the precision approach and landing phases of flight due to insufficient observables and/or untimely warning to the user beyond a specified time-to-alert in the event of a significant GPS failure.
They committed untimely penalties.
Teixeira's untimely miscues did.
