This process results in micro-metastatic, self-contained foci of cancer cells that persist clinically silent in multiple organs until one of these clusters acquires the necessary properties to establish invasive, colonizing growth, to become a detectable metastatic site and to re-disseminate systemically with a second wave of micro-metastasis.
In most cases, purifying selection on both members of the gene pair remains until one of the paired genes acquires an inactivating mutation(s) and undergoes degeneration to a pseudogene.
You are happy with your newly acquired knowledge until one day you discover that you need to do something a bit more ambitious, like repeat over an entire page all the laborious operations you have set up but with a new set of initial numbers.
Life was great until one day, our company got acquired by a large American enterprise that was looking to enter Canada.
However, he won't rest until he acquires rare species on far away remote islands – the ones that are not only impossible to get but to grow, too.
Pechiney was stripped of most of its subsidiaries after the nationalization of 1982, however, and produced mostly aluminum until it acquired American National Can, one of the world's largest packaging companies, in 1988.
It will fly low until it acquires Earth-escape velocity, so that the nuclear package will not fall on land in case of system malfunctioning.
Some industry analysts indicate that Endo will not likely blossom until Du Pont acquires another pharmaceutical concern.
The radar guides the interceptor until it acquires the target with its infrared sensor.
Iron is sometimes allowed to rust until it acquires a satisfactory colour, and then the process is arrested by lacquering.
Until BMW acquires the name, Mr. Kalbfell is not supposed to even pose in front of current Rolls-Royce models, much less promote them in any way.
