Sentence examples for until it is cleaved from inspiring English sources

The caspase-3 zymogen has essentially zero activity until it is cleaved by initiator caspases during apoptosis.

IL-1β is synthesised as pro-IL-1β, which remains in the cytosol until it is cleaved by caspase-1 and can be transported out of the cell.

Executioner caspase (caspase-3) appears as a zymogen in cells and has no activity until it is cleaved by an initiator caspase (caspase-8 or 9) after being stimulated by apoptotic stimuli.

The CFSE is a cell-permeable dye, that is, non-fluorescent until it is cleaved by intracellular esterases to yield a fluorescent carboxyfluorescein succinimidyl ester, that is, retained within the cells.

Synthesized as a single-chain polypeptide of ∼150 kDa, BTX has relatively little potency until it is cleaved by trypsin or bacterial enzymes into two chains, a heavy chain of 100 kDa responsible for binding to the target structure and a light chain of 50 kDa known as the toxifying chain.

The fact that 1-11E/vIL-10 is systemicalatenttent until it is cleaved by MMP in the arthritic joints is advantageous, as it will be activated only in inflamed joints where local MMPs, especially MMP-12 in early inflammation [ 19], cleaves it from the fusion, with little sequestering of the cytokine by systemic receptors [ 32]. 1-11E/vIL-10 maintained the specific binding to arthritic cartilage.

There, it is cleaved into its mature subunits, sucrase and isomaltase, by pancreatic proteases.

It is cleaved into its two component molecules following ingestion.

It is cleaved by the endoprotease furin, and a disulfide bond connects the two cleaved fragments.

LONGS PEAK, the highest mountain in Rocky Mountain National Park, looks like it was cleaved with a chisel.

Caspase-3 is the executioner protein of the apoptotic process and remains as inactive procaspase until it is being cleaved by activated initiator caspases such as caspase-8 or caspase-9.