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Until further improvements in the ANA-screening ELISA can be achieved, IIF-ANA should be considered the gold standard [ 4, 6, 16, 20].
These computational limitations make our strategy appropriate in large scale candidate gene studies, but may be limited in application to genome-wide association studies until further improvements in computing speed are realized or very large-scale computing resources are available.
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Next, the updated model is incrementally refined in the frequency domain and the minimization is repeated until the data misfit is reduced below a pre-specified criterion or until no further improvements are observed.
This process will continue until no further improvements can be made.
This process is repeated until no further improvements can be made to cluster tightness.
The algorithm then iterates (step 8) until no further improvements in the information theoretic score can be found.
A single-class model was examined first, and additional classes were specified until no further improvements in model fit were observed.
This was continued for all parameters, until no further improvements in fit were possible, which was the common minimum for all parameters.
Return to step 3, until no further improvements in the information theoretic score are found; Steps 1 4 proceed precisely as in the strict hierarchical clustering algorithm.
The Hill Climbing algorithm is a powerful local search algorithm that attempts to find the best solution by incrementally changing a single element of the solution until no further improvements can be found.
Participants were asked to adhere to the elimination diet until no further improvement was noted or until the period midpoint (typically 10 21 days), after which they were asked to reintroduce the omitted foods one at a time, starting with foods least likely to be a trigger, every 48 hours and report subsequent headaches.
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