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Median time until criteria for colic were no longer fulfilled was 7 days in both groups.
Stable disease (SD) was measured from the start of the treatment until criteria for disease progression were met.
If dependence or abuse criteria were not met for this drug, the assessment was repeated for the next most problematic drug until criteria were met.
However, ventilation could be performed longer in the groups with a Vt of 10 ml/kg with or without PEEP compared to all other groups until criteria to stop ventilation were met (data not shown).
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Mice were first trained on the MWM to learn the location of a submerged platform for 4 trials per day until criterion was reached (escape latency <25 s).
Training on each simple discrimination continued until criterion of at least 90% correct (27 of 30) was achieved.
The number of commission errors until criterion was reached did not significantly differ between groups, χ(2) = 2.27, p = 0.32.
If criterion performance was not achieved, training at that concentration was continued until criterion performance was obtained or for a maximum of 3 sessions.
Due to the adaptive nature of the task, there was a large variability in the amount of trials required until criterion was reached.
Repeat 3 to 7 until stop criteria are satisfied. .
Repeat steps 3 through 6 until termination criteria is satisfied. .
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