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The nadir CD4+ T-cell count was defined as the lowest level of immunosuppression since HIV diagnosis up until cohort entry.
3) Had a planned follow up period until cohort members reached at least adolescence.
Follow-up of the cohort was conducted for 5 7 years until cohort exit, which began in 2000.
Since healthy subjects were matched to HD patients, dosing of Cohort 2 was not initiated until Cohort 1 Groups 1 3 were complete and the dosing regimen confirmed.
We have thus obtained the complete dataset of annual mean NOx and NO2 concentrations at the residential addresses (including moving) of cohort members from 1971 until cohort baseline (1993 1997).
The association between mean NOx and NO2 levels since 1971 until cohort baseline (1993 97) and MD was analyzed using logistic regression, adjusting for confounders, and separately by menopause, smoking status, and obesity.
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In PD case cohorts, PD-outbreaks were defined to start the month the diagnosis was recorded and last until the cohort was terminated.
From 2004 until 2013, cohort members were interviewed annually using computer-assisted telephone interviews and in 2012 and 2013, respondents also had the option to complete their interviews online (NCVER 2010b).
Offspring survival required at least one adult on the nest until their cohort matured.
Measures of primary outcomes for our analysis were the number of life-years (LYs) and the number of quality-adjusted LYs (QALYs), measured from time of clinical diagnosis of diabetes until the cohort reaches 94 years of age or death.
Two cohorts were analyzed: patients who received adjuvant chemotherapy without trastuzumab, mostly until 2005 (cohort A), and patients who received adjuvant chemotherapy followed by or combined with trastuzumab (cohort B), starting from 2006, when trastuzumab was approved in Italy as adjuvant treatment.
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