Piaget's theory rests on the fundamental notion that the child develops through stages until he arrives at a stage of thinking that resembles that of an adult.
These studies are usually restricted to only a few lead candidates and postponed until a later stage of drug development since currently used analytical methods are laborious and costly and do not allow bioactivity assessment of metabolites, but only their identification.
CD4 is first expressed in the CD4+CD8+ double-positive (DP) thymocyte stage and, therefore, the CD4-Cre transgene is not expressed until a later stage of thymic development.
The compression of morbidity scenario assumes that as life expectancy rises, people will remain healthy longer and will not be in need of care until a later stage of life [ 12].
Interestingly, in a small study of dogs with pacing induced heart failure, CFR was reduced with progression of heart failure, but coronary endothelial function was preserved until a late stage of heart failure [ 28].
However, the proper timing for surgery is debatable: in the early stages of infection, patients may not be stable enough to be moved to the operating room, and patients may have little chance of surviving if surgery is delayed until a later stage of infection (3 ).
We can speculate that the tooth germs that form with experimental reactivation of this pathway or in ta2 chicken mutants could develop until an advanced stage of predentin deposition because the process to this point requires mainly collagen matrix deposition.
First coined by Kerr et al. [ 9], apoptotic morphology is characterized by a reduction of cellular volume, chromatin condensation, nuclear fragmentation, conservation of organelle ultrastructure, retention of plasma membrane (PM) integrity until an advanced stage of the death process, and subsequent formation of apoptotic bodies (Reviewed by Kroemer et al. [ 8]).
The drainage process is assumed to be similar to that for pure liquid until a stage is reached where the size of the cell agglomerates become equivalent to those of films and Plateau borders.
They were allowed free access to food and water and were observed once a week until terminal stage of the disease to record the onset and progression of clinical signs.
