Activation of "canonical" Wnt/β-catenin signaling in nearly all human colorectal adenocarcinomas (CRC) makes the Wnt pathway a promising yet untapped therapeutic target [1].
It would appear, therefore, that TPCs may offer an as yet untapped therapeutic target for the treatment of a variety of diseases.
CEO Steve Cousins says that he and his team see a "huge untapped opportunity" to target that vertical.
Isoform 5 of human lactate dehydrogenase (hLDH5), which catalyzes the final step in the glycolytic cascade (pyruvate to lactate), constitutes a relatively new and untapped anti-cancer target.
Sample mapping, molecule discovery, library mapping, and new clade visualization modules facilitate the interrogation of large (meta genomic sequence data sets for diverse downstream analyses, including, but not limited to, the identification of environments rich in untapped biosynthetic diversity, targeted molecule discovery efforts, and chemical ecology studies.
Protein protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development.
We have not found other reported smoking cessation interventions that targeted this untapped area of worksite health promotion.
Changes in cell-surface glycan patterns are markers of the presence of many different disease and cancer types, offering a relatively untapped niche for glycan-targeting reagents and therapeutics in diagnosis and treatment.
However, data about the frequency and distribution of analogous enzymes suggests that they may represent an untapped resource for such targets, since analogous enzymes share the same activity but possess different tertiary structures, an interesting attribute for drug development.
"What this does is target the enormous untapped quality that exists in many different communities, among people who are not yet considering teaching as a profession".
