The gained LLOQs for aflatoxins are higher than the maximum levels set in Commission Regulation (EC) No. 1881/2006 and its amendments [ 3], rendering this method unsuited for regulatory purposes.
To compound both of these problems, ChIP-Seq produces spatially distributed patterns of binding or histone modifications localised to specific regions of the genome (peaks); this feature, in particular, renders standard differential testing methods unsuited for the comparison of ChIP-Seq data sets.
But that's not because the subject is inherently unsuited to the scientific method.
Despite the accomplishments of the LD and DSB approaches to study recombination, these methods are unsuited for the characterization of sex effects: LD represents a sex average and sequencing protocols to map DSBs have been implemented only for male germ cells.
Always a perfectionist, Woods often insisted on unplugged, all-acoustic performances even in jazz premises apparently unsuited to such low-key methods, but his commitment and musicality usually won over the most unruly of audiences.
As Judea Pearl notes in his survey of the statistical literature on Simpson's paradox, statisticians had an aversion to talk of causal relations and causal inference that was based on the belief that the concept of causation was unsuited to and unnecessary for scientific methods of inquiry and theory construction (Pearl 2000, 173 181).
Standard normalization methods for microarrays are unsuited for CGH data since the distribution of intensities between different hybridizations cannot be assumed to be thesame.
Furthermore, concerns have been raised about pressure equilibration during flow interruption [ 8] and when small increases in resistance are used as provocation thresholds, the repeatability of the method was found unacceptably low and unsuited for clinical and research purposes [ 9].
He argued that such defenses fail because they do not recognise that there are different types of knowledge, that these different types are hierarchically arranged, and that the methods they employ are, by definition, unsuited to demonstrate certain things.
We base the approach on the fact that existing methods [16, 30] are complementary, i.e., the first method works well on a landmark subset the second method is unsuited for and vice versa.
