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Hence, in our hands commercially available antibodies were unsuitable to study RGS2 expression in native tissues.
Due to these restrictions, centenarians are unsuitable to study age-dependent variables (e.g. IGF-I) that may be involved in the modulation of the lifespan.
Conversely, currently available biomarkers of exposure appear to be unsuitable to study this issue, owing to their inability to reflect actual exposure to inorganic Se.
Chimpanzees are by far the best available animal model of HCV infection, but they are unsuitable to study chronic hepatitis and associated HCC, and restricted from medical research supported by the NIH or USA funding as an endangered species.
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However, although D. melanogaster has a widespread distribution, it has been suggested that its ecology made it an unsuitable model to study the causes of speciation in nature [ 68].
The book has recently repeatedly been judged as unsuitable for schoolchildren to study in the US educational system – and one can fully understand the feelings of anger and humiliation that many African American children and parents feel at having such a word repeatedly spoken in the classroom (the word appears 219 times in Twain's book).
The experimental groups are not considered consistently across different parts of the response, treatment assignments follow a pattern unsuitable to the study goal, proposed outcomes do not match the original investigation goal, and efforts to account for natural variability are inadequate.
Similarly, examined tumour factors might have been unsuitable to explore the study hypothesis and other tumour characteristics, such as vascular invasion and newer biochemical and genomic markers might have been more suitable.
At this stage the animals were then killed in order to remove and then weigh their kidneys (full urine albumin data sets being required for the repeated measure ANOVA analyses, making the study unsuitable to function as a longevity experiment).
At the investigators' discretion, patients who were unsuitable to participate in the study for any other reason were also excluded, e.g. those awaiting court appearances during the following 4-week period.
Exclusion criteria were (1) previous diagnosis of bowel cancer; (2) diagnosis of any cancer in the previous 6 months; (3) learning disability; (4) receiving regular colonoscopies; (5) experiencing significant cognitive decline; (6) clinically judged to be unsuitable to participate in the study (e.g. due to a terminal illness, mental health issue or inability to read English).
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