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However, as also shown in Table 4, there are numerous examples where unsuitable methodology has been used, with calculations based on clot amplitude.
Of these, 290 were excluded because they were not related to the evaluation of QOF, they lacked an equity dimension in the evaluation, their qualitative research focused on experiences or on the nature of the consultation, or unsuitable methodology was used to pronounce upon equity after the introduction of QOF.
Twelve publications appeared to be unrelated to equity because no subgroups had been defined [ 11- 15], the subgroups were only related to a geographical area [ 16, 17] or because of unsuitable methodology upon which to base conclusions regarding the defined subgroups [ 18- 22].
Whilst the assay may be utilised for environmental sampling or on differing biological samples, our data suggest that PCR performed directly on blood samples may be an unsuitable methodology and a potentially unachievable target for the routine diagnosis of enteric fever.
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In this discussion note, we reply to Bezuidenhout's (2013) claim that the narrow-temporal scale of language processing examined using the Visual World Paradigm makes this methodology unsuitable for studying perspective-taking in conversation.
The typical RNA fragment sizes of less than 300 bp make this methodology unsuitable for highly degraded RNA from FFPE samples [ 8].
These assays need to reach a considerable fragment size (up to 1.2 kb) to calculate the 3':5' ratio, which makes this methodology unsuitable for highly degraded RNA from FFPE samples.
Test engineers struggle to keep pace with these changes that, in combination with ever increasing design complexity, make previous tools and methodologies unsuitable.
However, many cells and cell lines are either refractory to or adversely affected by transfection, and the transient nature of this methodology renders it unsuitable for the generation of long-term cell lines of the desirable phenotype.
In our analysis, the relatively low efficiency and yield and high bias generated by the PCR-based methodologies renders them unsuitable for whole genome sequencing and representative amplification of precious DNA.
Nevertheless, there are evident features of each methodology that makes it unsuitable for a specific problem.
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