A factorial trial would be unsuitable for interventions that could not be used in conjunction with one another, such as two different minor surgical procedures for a dermatological problem.
Therapeutic combinations including immunotherapy may thus allow surgery to be performed in patients previously considered unsuitable for surgical intervention, potentially leading to a clinical cure, as in the current case.
If complete lung reexpansion or pleural apposition is not achieved and the patient is unsuitable for surgical intervention, pleurodesis should be still attempted.
Local therapies such as radiofrequency ablation and alcohol injection are alternatives for small tumors and patients unsuitable for surgical intervention with comparable success rates.
b A 74-year-old man with steep and shallow angle between common and external iliac arteries, making him unsuitable for percutaneous interventions .
One patient randomised to the lactate group was excluded from the analysis because the treating physician deemed the patient unsuitable prior to any intervention.
Some family members suffered from symptoms themselves or had such serious and difficult problems that participation in multi-family group intervention was unsuitable.
One patient was later switched to hemodialysis, and the other died of intestinal perforation 1 month later, considering that surgical intervention was unsuitable because of the patient's poor condition.
Consequently, DFs aid knowledge mobilisation and evidence implementation at the earliest possible stage, rather than waiting until the end of the study to find that the intervention is unsuitable for the health and social care environment.
Evidently, the low effect sizes make single genetic risk factors unsuitable for targeting preventive interventions, but there is increasing interest in investigating the extent to which genetic risk factors combined can improve the prediction of the disease.
This study describes the use of the Ilizarov external fixator (IEF) on patients who were unsuitable for other forms of operative intervention due to the small size of the proximal tibial fragment.
