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A more potent and less toxic derivative of wortmannin, PX-866, has been tested and shown to be effective in xenograft studies, but the lack of specificity of these inhibitors is likely to render them unsuitable for therapy.
Of these, five individuals had been asked to leave the ITP because they consumed alcohol during their stay, six individuals were deemed unsuitable for therapy by the clinical team, three individuals had to leave early because of complicated physical health difficulties that arose during their admission, and one individual had to leave early because a family member became unwell.
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Butyrate was given as an enema instead of oral therapy as in rabbits since the bad smell of butyrate makes it unsuitable for oral therapy in humans.
A careful medical history should be elicited prior to initiating statin therapy, with special emphasis on concomitant medications and medical illnesses which may make patients unsuitable for such therapy.
24 Based on these trials, the 2011 ACC/AHA focused update of the 2006 AF guidelines gave combination therapy with aspirin and clopidogrel a class IIb recommendation for stroke prevention in patients unwilling or unsuitable for anticoagulant therapy.
Cutting through or removal of nerves (neurectomy) is used in patients with short life expectancy who are unsuitable for drug therapy due to ineffectiveness or intolerance.
Sorafenib is approved for patients with mRCC who have failed, or are considered unsuitable for, cytokine therapy.
First, is apixaban safe and effective in patients who are unsuitable for VKA therapy, and thus not studied in ARISTOTLE?
Hence, SS-c may have the potential for therapeutic angiogenesis, but is unsuitable for cancer therapy [ 10].
The role of concurrent chemoradiotherapy (CRT) in patients with non-small-cell lung cancer (NSCLC) unsuitable for radical therapy but who require locoregional treatment has not been defined.
Bone scintigraphy maybe unsuitable for the therapy assessment of predominantly lytic disease without an associated osteoblastic response such as typically seen in myeloma, renal or thyroid cancers (i.e. cold spots on bone scans cannot be followed for progression).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com