Sentence examples for unstable locus from inspiring English sources

The close genetic distance between the two haplotype genomes might also explain the fact that WF1680 also had the second highest segregation distortion ratio for tested markers and the lowest locus density, both of which would cause unstable locus order.

High-level MI (>40% unstable loci) was detected in ten cases (12.7%) and low-level MI (1 40% unstable loci) in three (3.8%).

The definition of MSI (also known as MSI-high) is based on having ≥30% of unstable loci using monocleotide and dinucleotide markers; tumors with 10 29% of unstable loci in the panel are considered MSI-low.

All samples had been previously screened for MSI using 12 microsatellite markers, i.e. D2S115, D4S404, D5S178, IL9, D6S265, D7S490, D11S900, MYH6, TP53, D17S1176, D18S46, and D21S1407, and defined as MSI-H if there were more than 30% unstable loci, MSI-L less than 30% unstable loci, and microsatellite stable (MSS) no unstable loci (Ohmura et al, 2000; Ogata et al, 2001).

Paternal lifestyle, particularly smoking, has also been shown to be associated with increased germline DNA mutation rate at the unstable minisatellite locus CEB1 using 78 parent child trios.

The major mechanism of attenuation in Y. pestis EV76 is absence of an unstable pigmentation locus (Pgm) of approximately 102-kb containing a yersiniabactin transport system critical for the pathogenicity of this microorganism.

Common fragile sites (CFSs) are inherently unstable genomic loci that are recurrently altered in human tumor cells.

Five unstable microsatellite loci (D5S107, D5S406, ACTC, D13S153 and BAT26) were PCR-amplified in a single multiplex reaction using the previously reported primer pairs (one primer of each pair was 5′-labeled with FAM 34 and Type-it Microsatellite PCR kit (Qiagen, Valencia, CA, USA) following the supplier's protocol.

Engeström states the knot is "unstable" and the locus of initiative of the knot is always changing.

The major reason for attenuation is the loss of the unstable 102 kb pigmentation locus (Pgm) containing the Ybt (yersiniabactin) iron acquisition system.

We show that the unstable expression of this locus in REV1-deficient cells is explained by a single G4 motif located 3.5 kb downstream of the transcription start site (TSS).