The isolas have both stable (solid line) and unstable (dashed line) segments separated by fold bifurcation points (filled circles).
"Heterogeneous and unstable" cell lines might contribute more to the cancer research in the CSC era than the conventional "homogeneous and stable" cell lines.
Scott Barry, an analyst with Credit Suisse First Boston, said he would not be surprised if other financially unstable cruise lines shut down, in light of the fall in demand for such travel since the attacks on the World Trade Center and the Pentagon.
The lower branch is always unstable (dotted lines).
The unpredictability of the gene silencing process requires a thorough selection and early detection of unstable plant lines.
This study summarizes our experience in the overall occurrence of transgene silencing during the screening of N. attenuata plants and provides guidance in identifying and avoiding unstable plant lines.
Although "heterogeneous and unstable" cell lines have been considered as unsuitable research materials in the past, our findings here suggest that these types of cells might better be considered as "new major players" in the CSC era.
